초록접수 현황
| 21F-019 | 구연 발표 |
The Association between Frailty Index and Clinical Outcomes after Coronary Artery Bypass Grafting
Chan Hyeong Kim, MD, Yoonjin Kang, MD, Ji Seong Kim, MD, PhD, Suk Ho Sohn, MD, Ho Young Hwang, MD, PhD
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
Purpose : This study was conducted to evaluate the prognostic value of the frailty index based on laboratory data (FI-L) in patients who underwent coronary artery bypass grafting (CABG).
Methods : A total of 413 patients (67.0 ± 9.6 years, male 78.8%) who underwent CABG between 2018 and March 2021 were enrolled. The FI-L was calculated as the ratio of abnormal results among 32 preoperative parameters based on the patients’ vital sign and blood test results. The primary endpoint was all-cause mortality. Secondary endpoints were early mortality and postoperative complications. The predictive value of FI-L for endpoints were evaluated with multivariable analyses including logistic regression and Cox proportional hazards models and competing risk analysis.
Results : The mean FI-L was 21.3% ± 11.3%. The early mortality rate was 1.7% (n = 7). Postoperative complications included atrial fibrillation (n = 115, 27.8%), respiratory complication (n = 34, 8.2%), delirium (n = 20, 4.8%), acute kidney injury (n = 12, 2.9%), bleeding re-operation (n = 10, 2.4%), low-cardiac output syndrome (n = 9, 2.2%) and mediastinitis (n = 2, 0.5%). Late death occurred in 16 patients. One- and 3-year survival rates were 95.6% and 86.9%, respectively. Multivariable analyses showed that FI-L was a significant factor associated with all-cause mortality (hazard ratio, 95% confidence interval = 1.066, 1.026-1.108) and postoperative complications such as delirium (odds ratio, 95% confidence interval = 1.056, 1.018-1.095) and acute kidney injury (1.061, 1.009-1.115).
Conclusion : The FI-L might be a significant prognostic factor associated with all-cause mortality and postoperative complications for CABG patients.
Methods : A total of 413 patients (67.0 ± 9.6 years, male 78.8%) who underwent CABG between 2018 and March 2021 were enrolled. The FI-L was calculated as the ratio of abnormal results among 32 preoperative parameters based on the patients’ vital sign and blood test results. The primary endpoint was all-cause mortality. Secondary endpoints were early mortality and postoperative complications. The predictive value of FI-L for endpoints were evaluated with multivariable analyses including logistic regression and Cox proportional hazards models and competing risk analysis.
Results : The mean FI-L was 21.3% ± 11.3%. The early mortality rate was 1.7% (n = 7). Postoperative complications included atrial fibrillation (n = 115, 27.8%), respiratory complication (n = 34, 8.2%), delirium (n = 20, 4.8%), acute kidney injury (n = 12, 2.9%), bleeding re-operation (n = 10, 2.4%), low-cardiac output syndrome (n = 9, 2.2%) and mediastinitis (n = 2, 0.5%). Late death occurred in 16 patients. One- and 3-year survival rates were 95.6% and 86.9%, respectively. Multivariable analyses showed that FI-L was a significant factor associated with all-cause mortality (hazard ratio, 95% confidence interval = 1.066, 1.026-1.108) and postoperative complications such as delirium (odds ratio, 95% confidence interval = 1.056, 1.018-1.095) and acute kidney injury (1.061, 1.009-1.115).
Conclusion : The FI-L might be a significant prognostic factor associated with all-cause mortality and postoperative complications for CABG patients.
첨부파일 : Table and Figure.docx
책임저자: Ho Young Hwang
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
발표자: Chan Hyeong Kim, E-mail : byron9507@gmail.com