초록접수 현황
| 20F-165 | 구연 발표 |
Clinical significance of SUVmax in STAS presentation for primary lung adenocarcinoma
Kyung Soo Kim1, Mi Hyung Moon1, Kwan yong Hyun1, Jae Kil Park1, Kyo Young Lee2, Seok Whan Moon1
1Department of Thoracic and Cardiovascular Surgery, 2Departemnt of Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
Purpose : Pathologic findings of spread through air spaces (STAS) are known as the prognostic factor in surgically treated lung cancer patients. In planning limited pulmonary resection, STAS should be concerned in consideration of predictors, even after gaining enough margins. We aimed to evaluate the STAS presentation in patients with surgically resected primary lung adenocarcinoma.
Methods : 155 primary NSCLC patients underwent curative surgical resection from Sep 2019 to May 2020, and total 118 lung adenocarcinoma patients were enrolled. The clinicopathologic results such as SUVmax, tumor size, pathologic stage, tumor differentiation, pleural invasiveness, lymphovascular invasions were analyzed using logistic regression test.
Results : In 155 primary lung cancers, 21 (13.5%) cases showed STAS (+) (17/126 adenoca, 2/18 sqcc, and 2/5 SCLC). Of 118 adeonocarcinomas without induction treatment (53 males, 44.2%, mean age of 65.8±9.7 years), 55 (46.6%) limited resections were achieved. 24/118 (20.3%) GGN patients showing STAS (-) were excluded, and 94/118 (79.7%) invasive adenocarcinomas [14/94 (14.8%) STAS (+) and 80/94 (85.1%) STAS (–)] were classified. Mean tumor size was significantly larger (24.1±9.24 versus 18.0±11.1, p=0.04), and SUVmax was higher (7.4±3.9 versus 3.9±4.4, p=0.007), and lymphatic invasion was frequent (92.9% versus 50%, p=0.003) in STAS (+) group. In multivariate analysis, SUVmax revealed an independent predictor of STAS (+) (odd ratio,1.137 ; 95%CI: 1.007-1.283, p=0.038).
Conclusion : Preoperative SUVmax demonstrated predictive role in STAS presentation that limited resection can be avoided to decreased local tumor relapse in treating lung adenocarcinoma.
Methods : 155 primary NSCLC patients underwent curative surgical resection from Sep 2019 to May 2020, and total 118 lung adenocarcinoma patients were enrolled. The clinicopathologic results such as SUVmax, tumor size, pathologic stage, tumor differentiation, pleural invasiveness, lymphovascular invasions were analyzed using logistic regression test.
Results : In 155 primary lung cancers, 21 (13.5%) cases showed STAS (+) (17/126 adenoca, 2/18 sqcc, and 2/5 SCLC). Of 118 adeonocarcinomas without induction treatment (53 males, 44.2%, mean age of 65.8±9.7 years), 55 (46.6%) limited resections were achieved. 24/118 (20.3%) GGN patients showing STAS (-) were excluded, and 94/118 (79.7%) invasive adenocarcinomas [14/94 (14.8%) STAS (+) and 80/94 (85.1%) STAS (–)] were classified. Mean tumor size was significantly larger (24.1±9.24 versus 18.0±11.1, p=0.04), and SUVmax was higher (7.4±3.9 versus 3.9±4.4, p=0.007), and lymphatic invasion was frequent (92.9% versus 50%, p=0.003) in STAS (+) group. In multivariate analysis, SUVmax revealed an independent predictor of STAS (+) (odd ratio,1.137 ; 95%CI: 1.007-1.283, p=0.038).
Conclusion : Preoperative SUVmax demonstrated predictive role in STAS presentation that limited resection can be avoided to decreased local tumor relapse in treating lung adenocarcinoma.
책임저자: Seok-Whan Moon
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Republic of Korea
발표자: Kyung Soo Kim, E-mail : cskks@catholic.ac.kr