초록접수 현황
| 20F-128 | 구연 발표 |
Outcomes of salvage surgery for isolated loco-regional recurrence among non-small cell lung cancer patients
Jae Won Choi, Sumin Shin, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo and Young Mog Shim
Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Purpose : The aim of this study is to investigate the outcomes of salvage surgery for isolated postsurgical loco-regional recurrence among non-small cell lung cancer (NSCLC) patients.
Methods : Between January 2008 and December 2016, 199 patients who had isolated loco-regional recurrence after complete surgical resection for stage I to III NSCLC without induction treatment were identified. Of these, 21 patients who underwent salvage surgery were included this study, their surgical and oncologic outcomes were evaluated. Isolated loco-regional recurrence was defined as recurrence at the surgical margin, in the ipsilateral hilum or mediastinum without any evidence of distant metastasis.
Results : Median time to recurrence after initial surgery was 25.9 months and median post-recurrence survival was 48.2 months. The site of recurrence and matched treatment are as follows; bronchial stump in 6 patients who were treated with completion pneumonectomy (n=5) or bilobectomy (n=1), stapled margin in 7 who were treated with completion lobectomy (n=3) and wedge resection (n=4) and mediastinal lymph node (LN) in 7 who were treated with LN dissection followed by concurrent chemoradiotherapy (n=4), chemotherapy (n=2) and radiotherapy (n=1). Remaining 1 patient who had recurrence in both bronchial stump and multiple LN underwent LN dissection without resection of stump. During follow-up, of 10 patients with disease progression, 8 patients had distant metastasis. The 3 year post-recurrence overall survival and progression free survival were 90.0% and 51.7%, respectively.
Conclusion : Repeat surgery for loco-regional recurrence after complete surgical resection for NSCLC would be valuable option with favorable long-term survival rate.
Methods : Between January 2008 and December 2016, 199 patients who had isolated loco-regional recurrence after complete surgical resection for stage I to III NSCLC without induction treatment were identified. Of these, 21 patients who underwent salvage surgery were included this study, their surgical and oncologic outcomes were evaluated. Isolated loco-regional recurrence was defined as recurrence at the surgical margin, in the ipsilateral hilum or mediastinum without any evidence of distant metastasis.
Results : Median time to recurrence after initial surgery was 25.9 months and median post-recurrence survival was 48.2 months. The site of recurrence and matched treatment are as follows; bronchial stump in 6 patients who were treated with completion pneumonectomy (n=5) or bilobectomy (n=1), stapled margin in 7 who were treated with completion lobectomy (n=3) and wedge resection (n=4) and mediastinal lymph node (LN) in 7 who were treated with LN dissection followed by concurrent chemoradiotherapy (n=4), chemotherapy (n=2) and radiotherapy (n=1). Remaining 1 patient who had recurrence in both bronchial stump and multiple LN underwent LN dissection without resection of stump. During follow-up, of 10 patients with disease progression, 8 patients had distant metastasis. The 3 year post-recurrence overall survival and progression free survival were 90.0% and 51.7%, respectively.
Conclusion : Repeat surgery for loco-regional recurrence after complete surgical resection for NSCLC would be valuable option with favorable long-term survival rate.
책임저자: Sumin Shin
Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
발표자: Jae Won Choi, E-mail : mrjaewon.choi@gmail.com