초록접수 현황
| 20F-117 | 구연 발표 |
A propensity-matched analysis of sublobar resection versus stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) : Real world data from the Korean Association of Lung Cancer Registry (KALC-R)
Jeonghee Yun, Jong Ho Cho, Sumin Shin, Yong Soo Choi, Jhingook Kim, Jae Il Zo, Young Mog Shim, Hong Kwan Kim
Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Purpose : Sublobar resection and SBRT are alternative treatments of early-stage non-small cell lung cancer. We compared long-term survival outcome between sublobar resection and SBRT in patients with stage I NSCLC.
Methods : We retrospectively reviewed 389 patients with clinical stage I non-small cell lung cancer who underwent curative sublobar resection or SBRT in the Korean Association of Lung Cancer Registry (KALC-R) database from 2014 to 2016. After propensity score matching (1:3), the Kaplan-Meier method and log-rank test were used to compare overall survival. Competing risk analysis and Gray’s method were used to compare the cumulative incidence rate of recurrence.
Results : Of 389 patients included, 339 patients underwent sublobar resection and 50 patients underwent SBRT. In the unmatched cohort, sublobar resection was associated with significantly better 5-year survival compared with SBRT (log lank P < .001). However, there was no significant difference in the cumulative incidence of recurrence between the two groups (Gray’s test P = .824). After 1:3 propensity score matching, 87 patients were matched. In the matched cohort, sublobar resection group maintained better 5-year overall survival than SBRT group, but there was no statistically significant difference (log lank P = .083). Cumulative incidence of recurrence was similar between the two groups (Gray’s test P = .168).
Conclusion : Sublobar resection tends to have better long-term survival compared with SBRT in stage I non-small cell lung cancer.
Methods : We retrospectively reviewed 389 patients with clinical stage I non-small cell lung cancer who underwent curative sublobar resection or SBRT in the Korean Association of Lung Cancer Registry (KALC-R) database from 2014 to 2016. After propensity score matching (1:3), the Kaplan-Meier method and log-rank test were used to compare overall survival. Competing risk analysis and Gray’s method were used to compare the cumulative incidence rate of recurrence.
Results : Of 389 patients included, 339 patients underwent sublobar resection and 50 patients underwent SBRT. In the unmatched cohort, sublobar resection was associated with significantly better 5-year survival compared with SBRT (log lank P < .001). However, there was no significant difference in the cumulative incidence of recurrence between the two groups (Gray’s test P = .824). After 1:3 propensity score matching, 87 patients were matched. In the matched cohort, sublobar resection group maintained better 5-year overall survival than SBRT group, but there was no statistically significant difference (log lank P = .083). Cumulative incidence of recurrence was similar between the two groups (Gray’s test P = .168).
Conclusion : Sublobar resection tends to have better long-term survival compared with SBRT in stage I non-small cell lung cancer.
책임저자: Hong Kwan Kim
Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
발표자: Jeonghee Yun, E-mail : yjhms08@gmail.com