초록접수 현황
| 20F-107 | 포스터 발표 |
Salvage resection for local failure after stereotactic ablative radiotherapy for pulmonary malignancies
Eun Chae Kim, Samina Park, So Young Bae, Kwon Joong Na, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Young Tae Kim
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of Korea
Purpose : Salvage resection after radiotherapy is technically challenging and patients are considered to be vulnerable to postoperative complications. Outcomes for salvage lung resection after Stereotactic Ablative Radiotherapy (SABR) are not well established. We aimed to assess the feasibility and safety of salvage resection for local failure after SABR.
Methods : We queried patients who previously treated with SABR for primary and secondary lung malignancies from 2012 to 2018 and underwent salvage resection for failed SABR lesion. Detailed patient data were retrospectively collected. Short-term postoperative outcomes and recurrence rate were evaluated.
Results : Out of 741 patients who received SABR, 16 patients who underwent 17 salvage surgeries for local failures after SABR were identified. Preoperative pulmonary function were not deteriorated (mean FEV1 = 96% and mean DLCO = 74%). Pulmonary metastasis of colorectal cancer (n = 12, 71%) was the most common pathology. The median time to local recurrence was 15 months. Among 17 surgeries, VATS was conducted in 13 cases (76%) and R0 resection was achieved in 16 cases (94%). Eight lesions (47%) were required anatomical resections to achieve complete resection. A postoperative bleeding requiring surgical intervention occurred in one patient (6%) which was not related to previous radiation. There was no 30 and 90-day mortality. The median hospital day was 4 days. The median follow-up duration was 14 months. Three distant failures developed but isolated local failure was not found after salvage resection.
Conclusion : Salvage resection can be safe and effective in treating local failures after SABR. Eligible patients must be highly selected with care.
Methods : We queried patients who previously treated with SABR for primary and secondary lung malignancies from 2012 to 2018 and underwent salvage resection for failed SABR lesion. Detailed patient data were retrospectively collected. Short-term postoperative outcomes and recurrence rate were evaluated.
Results : Out of 741 patients who received SABR, 16 patients who underwent 17 salvage surgeries for local failures after SABR were identified. Preoperative pulmonary function were not deteriorated (mean FEV1 = 96% and mean DLCO = 74%). Pulmonary metastasis of colorectal cancer (n = 12, 71%) was the most common pathology. The median time to local recurrence was 15 months. Among 17 surgeries, VATS was conducted in 13 cases (76%) and R0 resection was achieved in 16 cases (94%). Eight lesions (47%) were required anatomical resections to achieve complete resection. A postoperative bleeding requiring surgical intervention occurred in one patient (6%) which was not related to previous radiation. There was no 30 and 90-day mortality. The median hospital day was 4 days. The median follow-up duration was 14 months. Three distant failures developed but isolated local failure was not found after salvage resection.
Conclusion : Salvage resection can be safe and effective in treating local failures after SABR. Eligible patients must be highly selected with care.
첨부파일 : Table and figure.pdf
책임저자: Samina Park
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of Korea
발표자: Eun Chae Kim, E-mail : kshhs1004@gmail.com