초록접수 현황
| 20F-104 | 구연 발표 |
Arterial Destruction in Patients with Behçet's Syndrome Undergoing Cardiovascular Surgery
(1)Wan Kee Kim, MD, (2)Jung-Hwan Kim, MD, (1)Seung Jun Song, MD, PhD, (2)Hyun-Chel Joo, MD, PhD, (2)Young-Nam Youn, MD, PhD, (2)Sak Lee, MD, PhD, (2)Kyung-Jong Yoo, MD, PhD, (2)Seung-Hyun Lee, MD, PhD
(1) Department of Cardiothoracic Surgery, Yonsei University Medical Center, Yongin, Gyeonggi-do, South Korea
(2) Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.
Purpose : Cardiovascular involvement in patients with Behçet's syndrome (BS) results devastating outcomes. In particular, arterial complications after cardiovascular surgery are often fatal.
Methods : Using the institutional database from 2000 to 2019, we retrieved 27 patients (47.2±10.0 years; 14.8% females) with BS who underwent aortic valve (AV) replacement, aorta or peripheral arterial repair. Primary interesting of study was arterial destruction, which was defined as rupture of the prior suture site requiring surgical correction. Multivariable cox regression analysis was conducted to detect predictors of arterial destruction. To predict an arbitrary cut-off point of the arterial destruction, cubic spline function was used. Secondary interesting was overall death.
Results : Fourteen (51.8%) AV and 3 (11.1%) thoracic/abdominal aorta replacements, 3 (11.1%) aortic arch vessel transfers, 6 (22.2%) femoral artery repair and 1 (3.7%) coronary arterial bypass were performed. During the mean follow-up of 79.3±50.6 months, arterial destruction occurred in 16 (59.3%) patients. On multivariable risk analysis, AV replacement (hazard ratio [HR], 3.15; 95% confidential interval [CI], 1.04-9.57) and the serum level of C-reactive protein (HR, 1.01; 95% CI, 1.00-1.02) were significantly associated with arterial destruction. The cut-off point was obtained at the C-reactive protein level of 10 (Central figure). A 3-year survival rate in these patients was 84.8±6.9%.
Conclusion : Arterial destruction occurred frequently after surgery in patients with BS. AV replacement and high level of serum C-reactive protein were related with arterial destruction.
Methods : Using the institutional database from 2000 to 2019, we retrieved 27 patients (47.2±10.0 years; 14.8% females) with BS who underwent aortic valve (AV) replacement, aorta or peripheral arterial repair. Primary interesting of study was arterial destruction, which was defined as rupture of the prior suture site requiring surgical correction. Multivariable cox regression analysis was conducted to detect predictors of arterial destruction. To predict an arbitrary cut-off point of the arterial destruction, cubic spline function was used. Secondary interesting was overall death.
Results : Fourteen (51.8%) AV and 3 (11.1%) thoracic/abdominal aorta replacements, 3 (11.1%) aortic arch vessel transfers, 6 (22.2%) femoral artery repair and 1 (3.7%) coronary arterial bypass were performed. During the mean follow-up of 79.3±50.6 months, arterial destruction occurred in 16 (59.3%) patients. On multivariable risk analysis, AV replacement (hazard ratio [HR], 3.15; 95% confidential interval [CI], 1.04-9.57) and the serum level of C-reactive protein (HR, 1.01; 95% CI, 1.00-1.02) were significantly associated with arterial destruction. The cut-off point was obtained at the C-reactive protein level of 10 (Central figure). A 3-year survival rate in these patients was 84.8±6.9%.
Conclusion : Arterial destruction occurred frequently after surgery in patients with BS. AV replacement and high level of serum C-reactive protein were related with arterial destruction.
책임저자: Seung-Hyun Lee, MD, PhD
Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-gu, Seoul 03722, Korea.
발표자: Wan Kee Kim, E-mail : sgwkwhite@gmail.com