초록접수 현황
| 19F-085 | 구연 미채택시 포럼 발표 |
Thoracic Cavity Volume Change after Lung Transplantation According to the Underlying end-stage Lung Disease
Woo Sik Yu¹, Chul Hwan Park², Hyo Chae Paik³, Jin Gu Lee³, Seulgi You⁴, Seokjin Haam¹
¹Department of Thoracic and Cardiovascular Surgery, Ajou University Hospital, Ajou University School of Medicine, Gyeonggi-do, Republic of Korea, ²Department of Radiology and the Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea, ³Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea, ⁴Department of Radiology, Ajou University Hospital, Ajou University School of Medicine, Gyeonggi-do, Republic of Korea
Purpose : End-stage lung diseases result in anatomical changes of the thoracic cavity, called ‘disease-related chest remodeling’. Also, anatomical changes may occur in the recipient’s thoracic cavity after lung transplantation (LTx). However, the evidence is insufficient. This study aimed to evaluate the thoracic cavity volume change after LTx according to the underlying end-stage lung disease.
Methods : We reviewed 89 patients (M:F = 48:41, mean age = 48.7 ± 12.2 year-old) who had pre-operative pulmonary function test (PFT), pre-operative chest computed tomography (CT) and 1-year follow-up chest CT after LTx retrospectively. These patients were divided into two groups according to their pre-operative PFTs: obstructive group (FEV1/FVC ratio < 70%); restrictive group (FEV1/FVC ratio > 70%). Anatomical CT lung volumes were obtained by using an auto-segmentation technique.
Results : Among the 89 patients, 26 were the obstructive group, and 63 were the restrictive group. In the obstructive group, post-LTx lung volume after 1 year was significantly smaller than pre-LTx lung volume (pre: 4662 ± 1296 ml, post: 3711 ± 891 ml, p<0.001). In the restrictive group, post-LTx lung volume was significantly larger than pre-LTx lung volume (pre: 2347 ± 709 ml, post: 3224 ± 919 ml, p=0.001). We found that restrictive group (β ± SE: 2031 ± 196, P<0.001) was independently associated with an increase in the lung volume.
Conclusion : After LTx, the remodeling of the thoracic cavity can happen, which is the opposite direction from the previous disease-related chest remodeling. This should be considered when donor selection.
Methods : We reviewed 89 patients (M:F = 48:41, mean age = 48.7 ± 12.2 year-old) who had pre-operative pulmonary function test (PFT), pre-operative chest computed tomography (CT) and 1-year follow-up chest CT after LTx retrospectively. These patients were divided into two groups according to their pre-operative PFTs: obstructive group (FEV1/FVC ratio < 70%); restrictive group (FEV1/FVC ratio > 70%). Anatomical CT lung volumes were obtained by using an auto-segmentation technique.
Results : Among the 89 patients, 26 were the obstructive group, and 63 were the restrictive group. In the obstructive group, post-LTx lung volume after 1 year was significantly smaller than pre-LTx lung volume (pre: 4662 ± 1296 ml, post: 3711 ± 891 ml, p<0.001). In the restrictive group, post-LTx lung volume was significantly larger than pre-LTx lung volume (pre: 2347 ± 709 ml, post: 3224 ± 919 ml, p=0.001). We found that restrictive group (β ± SE: 2031 ± 196, P<0.001) was independently associated with an increase in the lung volume.
Conclusion : After LTx, the remodeling of the thoracic cavity can happen, which is the opposite direction from the previous disease-related chest remodeling. This should be considered when donor selection.
책임저자: Seokjin Haam
Department of Thoracic and Cardiovascular Surgery, Ajou University Hospital, Ajou University School of Medicine, Gyeonggi-do, Republic of Korea
발표자: Woo Sik Yu, E-mail : yws081011@gmail.com