초록접수 현황
| 19F-071 | 구연 발표 |
Laser Absorbance and Raman Spectrum according to Subtype of Pulmonary Malignancies: Preliminary Study for Photoacoustic Ultrasonography
Wonkyoung Lee¹, Bong Kyu Kim¹, Hyun Jin Cho², Min-Woong Kang², Jin San Bok², Sung Joon Han², Piao Zhe², Woosik Han², Man-Shik Shim², Shin Kwang Kang², Jae Hyeon Yu², Myung Hoon Na²
¹Electronics and Telecommunications Research Institute, Daejeon, Republic of Korea, ²Department of Thoracic and Cardiovascular Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Purpose : Although photoacoustic spectroscopy is emerging novel imaging method to detect several abnormal conditions including cancer, it has not been applied to the lung that contain air because it is based on ultrasound. However, in thoracic surgical field with lungs collapsed, real-time photoacoustic imaging will help to locate the nodules in the lungs. We researched that laser absorbance and Raman spectrum in specific wavelengths between pulmonary malignancies and normal lung tissues as preliminary study for photoacoustic ultrasonography.
Methods : We prospectively experimented with fresh specimens of patients who underwent surgery for primary lung cancer or metastatic lung cancer from May 2019 to August 2019. Initially we found a specific wavelength showing the difference between cancer and normal tissue, and then measured a laser absorbance and Raman spectrum of several malignant tissues and normal tissues.
Results : Total 43 matched samples (experimental and control) from 20 patients were tested. Fifteen patients were primary lung cancer and 5 patients were metastatic adenocarcinoma. The difference in laser absorbance between tumor and normal tissue was most pronounced at 638nm. The absorbance of tumor tissue was higher than normal tissue. The laser absorbance did not show significant difference among the subtype of malignancies (sqcc vs. adenoca. vs. metastasis). Raman spectrum showed the differences among the subtype of malignancies.
Conclusion : We found a specific wavelength showing differences between lung cancer tissue and normal tissue and showed difference among the subtype of lung cancer using Raman spectrum measure. We are planning ex-vivo study to scan resected lung cancer specimen using photoacoustic ultrasound probe.
Methods : We prospectively experimented with fresh specimens of patients who underwent surgery for primary lung cancer or metastatic lung cancer from May 2019 to August 2019. Initially we found a specific wavelength showing the difference between cancer and normal tissue, and then measured a laser absorbance and Raman spectrum of several malignant tissues and normal tissues.
Results : Total 43 matched samples (experimental and control) from 20 patients were tested. Fifteen patients were primary lung cancer and 5 patients were metastatic adenocarcinoma. The difference in laser absorbance between tumor and normal tissue was most pronounced at 638nm. The absorbance of tumor tissue was higher than normal tissue. The laser absorbance did not show significant difference among the subtype of malignancies (sqcc vs. adenoca. vs. metastasis). Raman spectrum showed the differences among the subtype of malignancies.
Conclusion : We found a specific wavelength showing differences between lung cancer tissue and normal tissue and showed difference among the subtype of lung cancer using Raman spectrum measure. We are planning ex-vivo study to scan resected lung cancer specimen using photoacoustic ultrasound probe.
책임저자: Hyun Jin Cho
Department of Thoracic and Cardiovascular Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea
발표자: Hyun Jin Cho, E-mail : irainy79@naver.com