초록접수 현황
| 16F-254 | 구연 발표 |
Outcomes of Multidisciplinary Treatment Including Surgery in Malignant Pleural Mesothelioma
Ji Seong Kim, Kwan Yong Hyun, Samina Park, Yoohwa Hwang, Hyun Joo Lee, In Kyu Park, Chang Hyun Kang, Young Tae Kim
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Background : Multidisciplinary approach including surgery such as extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D) is a standard treatment in malignant pleural esothelioma (MPM). However, Korean studies about treatment of MPM are scarce due to rarity of MPM.In this study, we analyzed treatment outcomes of MPM.
Methods : Consecutive 29 patients who diagnosed as MPM from April, 1998 to July, 2015 were
retrospectively reviewed. Demographic data, clinic-pathologic data were achieved by review of medical records. The last follow-up date was 31st, August, 2016. Clinical manifestation and overall survival rates were analyzed and prognoses of surgery group and non-surgery group were compared.
Results : Sixteen (55%) patients underwent curative surgery. (EPP - 11, P/D - 1,pulmonary & chest wall resection - 4). In non-surgery group, 12 of 13 patients underwent chemotherapy including 1 patient with palliative radiotherapy. In surgery group, 7 patients (43.7%) received neoadjuvant chemotherapy and 10 patients (62.5%) received adjuvant chemo-radiation therapy. Median hospital-stay duration was 18 days (5~153). Postoperative complications were 4 tachyarrhythmias, 1 pulmonary thromboembolism, 1 pneumonia, and 3 wound complications. There was no 30-days or in-hospital mortality. Median follow-up duration was 10.6 months. Median survival time was 10.6 months and overall 3-year survival rate was 25%. In surgery group, median survival time was 10.5 months and 3-year survival rate was 31.3%. In non-surgery group, median survival time was 6.1 months and 3-year survival rate was 16.7%.There was no difference in survival rate between two groups. (p=0.47)
Conclusion : Historical data showed no survival gain of multidisciplinary treatment including surgery with obsolete treatment strategy. Prospective study with contemporary treatment strategy is in need for the treatment of MPM in Korea.
Methods : Consecutive 29 patients who diagnosed as MPM from April, 1998 to July, 2015 were
retrospectively reviewed. Demographic data, clinic-pathologic data were achieved by review of medical records. The last follow-up date was 31st, August, 2016. Clinical manifestation and overall survival rates were analyzed and prognoses of surgery group and non-surgery group were compared.
Results : Sixteen (55%) patients underwent curative surgery. (EPP - 11, P/D - 1,pulmonary & chest wall resection - 4). In non-surgery group, 12 of 13 patients underwent chemotherapy including 1 patient with palliative radiotherapy. In surgery group, 7 patients (43.7%) received neoadjuvant chemotherapy and 10 patients (62.5%) received adjuvant chemo-radiation therapy. Median hospital-stay duration was 18 days (5~153). Postoperative complications were 4 tachyarrhythmias, 1 pulmonary thromboembolism, 1 pneumonia, and 3 wound complications. There was no 30-days or in-hospital mortality. Median follow-up duration was 10.6 months. Median survival time was 10.6 months and overall 3-year survival rate was 25%. In surgery group, median survival time was 10.5 months and 3-year survival rate was 31.3%. In non-surgery group, median survival time was 6.1 months and 3-year survival rate was 16.7%.There was no difference in survival rate between two groups. (p=0.47)
Conclusion : Historical data showed no survival gain of multidisciplinary treatment including surgery with obsolete treatment strategy. Prospective study with contemporary treatment strategy is in need for the treatment of MPM in Korea.
책임저자: In Kyu Park
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
발표자: Ji Seong Kim, E-mail : ttee03@gmail.com