초록접수 현황
| 16F-242 | 구연 발표 |
The Prognosis of Invasive Adenocarcinoma Presenting as Ground-glass Opacity after Sublobar Resection
Youngkyu Moon¹, Kyo Young Lee², Sook Whan Sung¹, Jae Kil Park¹
¹Department of Thoracic and Cardiovascular Surgery, ²Department of Hospital Pathology, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Korea
Background : Ground glass opacity (GGO) generally associated with the lepidic component of lung adenocarcinoma, and in many cases, sublobar resection is chosen for surgical treatment. However, in some cases, GGO nodules have been associated with invasive adenocarcinomas, where a lepidic component is minimal or absent. The purpose of this study is to evaluate the prognosis of invasive adenocarcinoma presenting as GGO nodules after sublobar resection.
Methods : We conducted a retrospective chart review of 233 patients who were treated for stage I non–small cell lung cancer presenting as GGO-predominant tumor (C/T ratio <0.5) in computed tomography and who underwent curative resection (lobectomy or sublobar resection) with clear resection margins. We compared the recurrence free survival among 4 groups (Group A : invasive adenocarcinoma underwent sublobar resection, Group B : non-invasive adenocarcinoma underwent sublobar resection, Group C : invasive adenocarcinoma underwent lobectomy, Group D : non-invasive adenocarcinoma underwent lobectomy).
Results : There were no differences in clinical characteristics among the three groups. There were no differences in the 5-year recurrence-free survival rate among four groups (91.7%, 100%, 97.6%, and 100%, respectively, p=0.393). 5-year overall survival rates were also not different among four groups (100%, 96.8%, 98.9%, and 98.3%, p=0.861). The recurrences occurred only in patients with invasive adenocarcinoma. In the multivariate analysis, sublobar resection was not a significant risk factor for the recurrence in invasive adenocarcinoma.
Conclusion : Invasive adenocarcinoma presenting as GGO has good prognosis after sublobar resection. In the case of GGO-predominant tumor, sublobar resection can be a feasible option for curative surgery irrespective of histologic subtypes. And, it is not necessary to perform the completion lobectomy in the patient with the GGO tumor which has revealed as invasive adenocarcinoma after sublobar resection.
Methods : We conducted a retrospective chart review of 233 patients who were treated for stage I non–small cell lung cancer presenting as GGO-predominant tumor (C/T ratio <0.5) in computed tomography and who underwent curative resection (lobectomy or sublobar resection) with clear resection margins. We compared the recurrence free survival among 4 groups (Group A : invasive adenocarcinoma underwent sublobar resection, Group B : non-invasive adenocarcinoma underwent sublobar resection, Group C : invasive adenocarcinoma underwent lobectomy, Group D : non-invasive adenocarcinoma underwent lobectomy).
Results : There were no differences in clinical characteristics among the three groups. There were no differences in the 5-year recurrence-free survival rate among four groups (91.7%, 100%, 97.6%, and 100%, respectively, p=0.393). 5-year overall survival rates were also not different among four groups (100%, 96.8%, 98.9%, and 98.3%, p=0.861). The recurrences occurred only in patients with invasive adenocarcinoma. In the multivariate analysis, sublobar resection was not a significant risk factor for the recurrence in invasive adenocarcinoma.
Conclusion : Invasive adenocarcinoma presenting as GGO has good prognosis after sublobar resection. In the case of GGO-predominant tumor, sublobar resection can be a feasible option for curative surgery irrespective of histologic subtypes. And, it is not necessary to perform the completion lobectomy in the patient with the GGO tumor which has revealed as invasive adenocarcinoma after sublobar resection.
책임저자: Jae Kil Park
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Korea
발표자: Youngkyu Moon, E-mail : mykae@catholic.ac.kr