초록접수 현황
| 16F-231 | 포럼 발표 |
The Identification of Aerogenous Spread is Poor Prognostic Factor in Squamous Cell Carcinoma of Lung
Bubse Na¹, Sukki Cho¹, Jin Haeng Chung², Kwhanmien Kim¹, Sanghoon Jheon¹
¹Department of Thoracic and Cardiovascular Surgery, ²Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Korea
Background : The aim of this study was to evaluate the prognostic effect of aerogenous spread found in squamous cell carcinoma of lung (LSCC).
Methods : Retrospective review was done in 138 patients who underwent curative resection for LSCC from 2011 to 2013. Aerogenous spread is morphologically defined as the presence of non-attached micropapillary cell clusters in the alveolar space seen at a distance of at least one low power field from main mass.
Results : Aerogenous spread was identified in 37 patients (26.8%). The presence of aerogenous spread was not associated with pathologic stage, differentiation, and vascular invasion, but with lymphatic invasion only. During median follow up of 38 months, recurrence was developed in 36 patients, and 3-year recurrence-free survival was 72.7%. Univariate analysis using log-rank test of Kaplan-Meier methods showed smoker, wedge resection, high pathologic staging, lymphovascular invasion, and presence of aerogenous spread were poor prognostic factors. By multivariate analysis, pathologic staging, wedge resection, and presence of aerogenous spread were independent worse prognostic factors in LSCC.
Conclusion : The identification of aerogenous spread is independently associated with risk of recurrence in squamous cell carcinoma of lung.
Methods : Retrospective review was done in 138 patients who underwent curative resection for LSCC from 2011 to 2013. Aerogenous spread is morphologically defined as the presence of non-attached micropapillary cell clusters in the alveolar space seen at a distance of at least one low power field from main mass.
Results : Aerogenous spread was identified in 37 patients (26.8%). The presence of aerogenous spread was not associated with pathologic stage, differentiation, and vascular invasion, but with lymphatic invasion only. During median follow up of 38 months, recurrence was developed in 36 patients, and 3-year recurrence-free survival was 72.7%. Univariate analysis using log-rank test of Kaplan-Meier methods showed smoker, wedge resection, high pathologic staging, lymphovascular invasion, and presence of aerogenous spread were poor prognostic factors. By multivariate analysis, pathologic staging, wedge resection, and presence of aerogenous spread were independent worse prognostic factors in LSCC.
Conclusion : The identification of aerogenous spread is independently associated with risk of recurrence in squamous cell carcinoma of lung.
책임저자: Sukki Cho
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Korea
발표자: Bubse Na, E-mail : otlkin87@gmail.com