초록접수 현황
| 16F-206 | 구연 발표 |
Long-term Oncological Effects of Positive Malignant Cells in Pleural Lavage Cytology for Respectable Lung Cancer
Byung Kwon Chong, Han Pil Lee, Kang Hoon Lee, Jin San Bok, Su Kyung Hwang, Se Hoon Choi, Hyeong Ryul Kim, Dong Kwan Kim, Seung Il Park, Yong-Hee Kim
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
Background : To clarify the usefulness of pleural lavage cytology (PLC) in assessment of primary lung cancer, long term follow up results of large Cohort is essential.
Methods : Between January 2003 and December 2013, 5676 patients underwent surgical resection for primary lung cancer in ASAN medical center (Table 1). We identified 1222 patients who had performed PLC with 500mL of saline irrigation right after thoracotomy. Patients with pleural adhesion or effusion were excluded. Kaplan-Meier were formulated to delineate the overall survival and recurrence-free rates. To identify the predictors of mortality and recurrence, Cox proportional hazard models were applied.
Results : Median follow up duration was 61.2 months (29.2-86.5 months). Malignancy positive upon cytology was 3.8% (n = 47). There were no significant differences in local and distal recurrence rate between two groups (p = 0.144, 0.425, respectively). However overall survival (p = 0.018) and recurrence free survival (p = 0.029) were significantly lower in PLC(+) patients (Figure 1). In subgroup analysis, PLC(+) had more prognostic importance in stage II patients with the p-value of 0.039 in overall survival rate. When survivals of PLC(+) were compared to that of PLC(-) by stage, the result was similar to stage III (Figure 2). Prognostic indicators of survival were positive PLC (p = 0.047), male sex (p = 0.001), involvement of visceral pleura (p = 0.015), T stage 2 (p = 0.010) & pathologic stage IIIa (p = 0.001) (Table 2).
Conclusion : Examination of PLC right after thoracotomy can be a prognostic indicator for NSCLC patients.
Methods : Between January 2003 and December 2013, 5676 patients underwent surgical resection for primary lung cancer in ASAN medical center (Table 1). We identified 1222 patients who had performed PLC with 500mL of saline irrigation right after thoracotomy. Patients with pleural adhesion or effusion were excluded. Kaplan-Meier were formulated to delineate the overall survival and recurrence-free rates. To identify the predictors of mortality and recurrence, Cox proportional hazard models were applied.
Results : Median follow up duration was 61.2 months (29.2-86.5 months). Malignancy positive upon cytology was 3.8% (n = 47). There were no significant differences in local and distal recurrence rate between two groups (p = 0.144, 0.425, respectively). However overall survival (p = 0.018) and recurrence free survival (p = 0.029) were significantly lower in PLC(+) patients (Figure 1). In subgroup analysis, PLC(+) had more prognostic importance in stage II patients with the p-value of 0.039 in overall survival rate. When survivals of PLC(+) were compared to that of PLC(-) by stage, the result was similar to stage III (Figure 2). Prognostic indicators of survival were positive PLC (p = 0.047), male sex (p = 0.001), involvement of visceral pleura (p = 0.015), T stage 2 (p = 0.010) & pathologic stage IIIa (p = 0.001) (Table 2).
Conclusion : Examination of PLC right after thoracotomy can be a prognostic indicator for NSCLC patients.
책임저자: Yong-Hee Kim
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
발표자: Byung Kwon Chong, E-mail : pogri@naver.com