초록접수 현황
| 16F-168 | 구연 발표 |
Analysis of High-risk Age by using Expected Survival Time (EST) in Elderly Patients with Resected NSCLC
Seokkee Lee, Jee Won Shu, Kyung Sik Nam, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Chae Paik, Kyung Young Chung
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Background : Age is a risk factor for overall survival (OS) of patients with resected non-small cell lung cancer (NSCLC). Elderly patient was defined ≥ 70 years, but recently these patients have increased in receiving surgical treatment. Therefore, we want to judge the high-risk age of resected NSCLC in elderly patients.
Methods : This retrospective study was conducted to assess the Expected Survival Time (EST) in elderly patients with resected NSCLC between January 1998 and December 2012. This study was composed of patients aged 65 and over. EST was calculated by subtracting age at surgery from life expectancy at each year. All patients were divided based on EST ≤ 5, and p-value was compared with the results of grouping by other ages (≥ 70, ≥ 75, and ≥ 80).
Results : 941 patients were enrolled in this study. Their mean age was 71.2 years, and there were 692 (73.5%) men. The mean EST was 6.6 years. Lobectomy (709 cases, 75.7%) and adenocarcinoma (477 cases, 50.7%) was the most common operation and histology. Stage I occurred more frequently (517 cases, 45.9%) than other stages. The study period was divided into 3 groups, each with 5 years. In log-rank test, aging over 70, 75 and 80 years affected the OS (p=0.026, p=0.016, p=0.037), also EST ≤ 5 had statistically significant difference in OS (p<0.001). Furthermore, EST ≤ 5 was independent risk factor for OS (HR, 1.697; CI, 1.376 – 2.093; p<0.001) in multivariate analysis.
Conclusion : High-risk age of surgical resection in NSCLC has been continually changing with the passage of time. In this study, we try to consistently demonstrate about high-risk age assessment by using EST. We thought that EST was more specific age-criteria rather than dividing by 70, 75 or 80 years.
Methods : This retrospective study was conducted to assess the Expected Survival Time (EST) in elderly patients with resected NSCLC between January 1998 and December 2012. This study was composed of patients aged 65 and over. EST was calculated by subtracting age at surgery from life expectancy at each year. All patients were divided based on EST ≤ 5, and p-value was compared with the results of grouping by other ages (≥ 70, ≥ 75, and ≥ 80).
Results : 941 patients were enrolled in this study. Their mean age was 71.2 years, and there were 692 (73.5%) men. The mean EST was 6.6 years. Lobectomy (709 cases, 75.7%) and adenocarcinoma (477 cases, 50.7%) was the most common operation and histology. Stage I occurred more frequently (517 cases, 45.9%) than other stages. The study period was divided into 3 groups, each with 5 years. In log-rank test, aging over 70, 75 and 80 years affected the OS (p=0.026, p=0.016, p=0.037), also EST ≤ 5 had statistically significant difference in OS (p<0.001). Furthermore, EST ≤ 5 was independent risk factor for OS (HR, 1.697; CI, 1.376 – 2.093; p<0.001) in multivariate analysis.
Conclusion : High-risk age of surgical resection in NSCLC has been continually changing with the passage of time. In this study, we try to consistently demonstrate about high-risk age assessment by using EST. We thought that EST was more specific age-criteria rather than dividing by 70, 75 or 80 years.
책임저자: Kyung Young Chung
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
발표자: Seokkee Lee, E-mail : cslsk8@yuhs.ac