초록접수 현황
| 16F-158 | 구연 발표 |
Predictors of Long-term Survival after Recurrence in Completely Resected Non-Small Cell Lung Cancer
Jae-IK Lee¹, Kun Woo Kim¹, Won-Jun Choi², Kook-Yang Park¹, Chul-Hyun Park¹, Chang-Hyu Choi¹, Kuk-Hui Son¹, Seok-In Lee¹, So-Young Lee¹
¹Department of Thoracic and Cardiovascular Surgery, ²Department of Occupational and Environmental Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
Background : The aims of this retrospective study were 1) to define long-term postrecurrence survival (PRS) in completely resected non-small cell cancer (NSCLC), and 2) to determine which clinical factors might be predictive for this favorable outcome.
Methods : The clinicopathological characteristics of 121 patients with recurrence after complete resection of NSCLC between 2004 and 2014 were reviewed.
Results : Five-year PRS rate was 28.6 % (mean follow-up; 24 months, no follow-up loss). The hazard rate curve displayed a peak about 6–12 months after recurrence, and 93.4% of deaths occurred within 3 years (Fig). Based on event dynamics, 31 long-term survivors (LTS, living longer than 3 years) records were retrieved and compared with those of 79 short-term survivors (STS, dying within 3 years). Five-year PRS rate of LTS group was 85.3%. The median PRS time of STS group was 9.2 months. Independent predictors of LTS were a disease-free interval (DFI) longer than 14 months (HR=0.059; p=0.001), adenocarcinoma (HR=0.175; p=0.047), Eastern Cooperative Oncology Group Performance Status (ECOG PS) – 0 (HR=0.207; p=0.033), single organ recurrence (HR=0.077; p=0.004), definitive local therapy (DLT) (HR=0.068; p=0.002). In cases of single organ recurrence, the 5-year PRS rates of DLT (+) and DLT (-) group were 57.7% and 24.2%, respectively (p=0.014).
Conclusion : These data confirm the existence of LTS in patients with recurrence after complete resection of NSCLC. Shorter DFI, adenocarcinoma, good ECOG PS, single organ recurrence, and DLT are associated with good prognosis after recurrence. When the recurrent lesions are limited to a single organ, DLT should be considered to achieve long-term PRS.
Methods : The clinicopathological characteristics of 121 patients with recurrence after complete resection of NSCLC between 2004 and 2014 were reviewed.
Results : Five-year PRS rate was 28.6 % (mean follow-up; 24 months, no follow-up loss). The hazard rate curve displayed a peak about 6–12 months after recurrence, and 93.4% of deaths occurred within 3 years (Fig). Based on event dynamics, 31 long-term survivors (LTS, living longer than 3 years) records were retrieved and compared with those of 79 short-term survivors (STS, dying within 3 years). Five-year PRS rate of LTS group was 85.3%. The median PRS time of STS group was 9.2 months. Independent predictors of LTS were a disease-free interval (DFI) longer than 14 months (HR=0.059; p=0.001), adenocarcinoma (HR=0.175; p=0.047), Eastern Cooperative Oncology Group Performance Status (ECOG PS) – 0 (HR=0.207; p=0.033), single organ recurrence (HR=0.077; p=0.004), definitive local therapy (DLT) (HR=0.068; p=0.002). In cases of single organ recurrence, the 5-year PRS rates of DLT (+) and DLT (-) group were 57.7% and 24.2%, respectively (p=0.014).
Conclusion : These data confirm the existence of LTS in patients with recurrence after complete resection of NSCLC. Shorter DFI, adenocarcinoma, good ECOG PS, single organ recurrence, and DLT are associated with good prognosis after recurrence. When the recurrent lesions are limited to a single organ, DLT should be considered to achieve long-term PRS.
책임저자: Jae-Ik Lee
Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
발표자: Jae-IK Lee, E-mail : pittz@hanmail.net