초록접수 현황
| 16F-018 | 구연 발표 |
Patterns of Recurrence in Curatively Resected Stage I Lung Cancer.
Kanghoon Lee, Seung-Il Park, Yong-Hee Kim, Hyeong Ryul Kim, Se Hoon Choi, Su Kyung Hwang, Jin San Bok, Han Pil Lee, Byung Kwon Chong, Dong Kwan Kim
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
Background : The patterns of recurrence after curative resection for pathologically stage I non-small cell lung cancer(NSCLC) were investigated according to the cell type.
Methods : The medical records of stage I NSCLC patients who undergone curative resection between 2000 and 2009 were reviewed.
Results : Total 940 patients with pathologically proven stage I NSCLC were included. Patients with lepidic-type adenocarcinoma(LTA) were 74, other adenocarcinoma(ADC) 580, and squamous cell carcinoma(SCC) 246. Median length of follow-up was 62 months(3~189), median survival was 146 months, and median disease-free survival(DFS) was 109 months. During follow-up, recurrence occurred in 221 patients(23.5%). Number of patients who developed tumor recurrence is grouped by every 6 months. Incidence of recurrence was peaked within 2 years after resection, then gradually decreased thereafter. Recurrence LTA(AIS/MIA) group was significantly rare(13.5%) throughout the all follow-up period(median DFI of 60months), and its distribution shows relatively even distribution. Comparing ADC and SCC, ADC seemed to show better 5-year OS in univariate analysis(p=0.003), but not in multivariate analysis. Furthermore, there were no significant difference in 5-year DFS(p=0.331). ADC shows higher proportion of distant metastasis, even though ADC group has lower T-stage. SCC shows higher incidence of local recurrence.
Conclusion : Recurrence of ADC occured within 2 years after resection, and shows higher proportion of distant metastasis(74.0% Vs. 57.2) even though ADC group has lower T-stage. Most of recurrence of both ADC and SCC groups were peaked within 2 years after resection. LTA group shows significantly delayed pattern of recurrence.
Methods : The medical records of stage I NSCLC patients who undergone curative resection between 2000 and 2009 were reviewed.
Results : Total 940 patients with pathologically proven stage I NSCLC were included. Patients with lepidic-type adenocarcinoma(LTA) were 74, other adenocarcinoma(ADC) 580, and squamous cell carcinoma(SCC) 246. Median length of follow-up was 62 months(3~189), median survival was 146 months, and median disease-free survival(DFS) was 109 months. During follow-up, recurrence occurred in 221 patients(23.5%). Number of patients who developed tumor recurrence is grouped by every 6 months. Incidence of recurrence was peaked within 2 years after resection, then gradually decreased thereafter. Recurrence LTA(AIS/MIA) group was significantly rare(13.5%) throughout the all follow-up period(median DFI of 60months), and its distribution shows relatively even distribution. Comparing ADC and SCC, ADC seemed to show better 5-year OS in univariate analysis(p=0.003), but not in multivariate analysis. Furthermore, there were no significant difference in 5-year DFS(p=0.331). ADC shows higher proportion of distant metastasis, even though ADC group has lower T-stage. SCC shows higher incidence of local recurrence.
Conclusion : Recurrence of ADC occured within 2 years after resection, and shows higher proportion of distant metastasis(74.0% Vs. 57.2) even though ADC group has lower T-stage. Most of recurrence of both ADC and SCC groups were peaked within 2 years after resection. LTA group shows significantly delayed pattern of recurrence.
책임저자: Dong Kwan Kim
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
발표자: Kanghoon Lee, E-mail : kumcjklee@gmail.com