초록접수 현황
| 15F-208 | 구연 발표 |
Comparison of Postoperative Prognosis between Solid and Part-solid Node-Negative Lung Adenocarcinoma with Invasive Component Size Less than 20mm
Kyung Wook Shin, Sukki Cho, Sungjoon Park, Hyo-Jun Jang, Eunjue Yi, Kwhanmien Kim, Sanghoon Jheon
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea
Background : We hypothesize the prognosis of part-solid adenocarcinoma (AC) might be better than solid AC if the size of invasive component were same. Our study aim to compare the prognosis of solid AC less than 20 mm with part-solid AC with invasive tumor size less than 20 mm in node-negative AC.
Methods : From prospective lung cancer database between 2003 and 2012, 191 patients were selected whose size of invasive component was less than 20 mm in solid or part-solid in pathologic node-negative adenocarcinoma. Enrolled patients were categorized into two groups; Group1; solid AC consists of only invasive component, and Group 2; part-solid AC consists of both in situ and invasive component. 5- year recurrence free survival (RFS) and overall survival (OS) were compared by Kaplan- Meier survival analysis and Log-rank test.
Results : There were 92 patients in group 1 and 99 patients in group 2. The mean size of invasive component and total lesion was 16.0 mm and 15.2 mm (p=0.06), and 16.0 mm and 21.0 mm (p<0.001) in group 1 and group 2, respectively. Lymphovascular invasion and high SUVmax were significantly more common in group 1. There were significantly more female, non-smoker, and lepidic subtype in group 2. Proportion of limited resection was higher in group 2. Visceral pleural invasion was not different between two groups. Median follow up duration was 54.2 months (8-126). The 5-year OS rates of Group 1 and Group 2 were 90.3 and 93.8% (p=0.160), and RFS were 84.0 and 93.7% (p=0.037), respectively.
Conclusion : Even though total size of part-solid AC was larger than that of solid AC, the prognosis of part-solid AC was better than that of solid AC in node-negative AC with invasive component size of less than 20 mm.
Methods : From prospective lung cancer database between 2003 and 2012, 191 patients were selected whose size of invasive component was less than 20 mm in solid or part-solid in pathologic node-negative adenocarcinoma. Enrolled patients were categorized into two groups; Group1; solid AC consists of only invasive component, and Group 2; part-solid AC consists of both in situ and invasive component. 5- year recurrence free survival (RFS) and overall survival (OS) were compared by Kaplan- Meier survival analysis and Log-rank test.
Results : There were 92 patients in group 1 and 99 patients in group 2. The mean size of invasive component and total lesion was 16.0 mm and 15.2 mm (p=0.06), and 16.0 mm and 21.0 mm (p<0.001) in group 1 and group 2, respectively. Lymphovascular invasion and high SUVmax were significantly more common in group 1. There were significantly more female, non-smoker, and lepidic subtype in group 2. Proportion of limited resection was higher in group 2. Visceral pleural invasion was not different between two groups. Median follow up duration was 54.2 months (8-126). The 5-year OS rates of Group 1 and Group 2 were 90.3 and 93.8% (p=0.160), and RFS were 84.0 and 93.7% (p=0.037), respectively.
Conclusion : Even though total size of part-solid AC was larger than that of solid AC, the prognosis of part-solid AC was better than that of solid AC in node-negative AC with invasive component size of less than 20 mm.
책임저자: Sukki Cho
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea
연락처 : Kyung Wook Shin, Tel: 0317876255 , E-mail : sinkw80@gmail.com
