초록접수 현황
| 15F-052 | 구연 발표 |
Aging-related Diameter Change of the Thoracic Aorta in the General Population – Long Term CT Study
김수현, 김정희, 김동중, 정수련, 김준성, 임청, 박계현
서울대학교 의과대학 분당서울대학교병원 흉부외과학교실
Background : It is already known that the aorta dilates with aging. However, there has been scanty data showing the detailed feature of such change by long-term serial imaging on the same subjects. This study aimed to investigate the aging-related aortic dilatation according to the demographic features in the patient group which is believed to be similar to the general population.
Methods : By performing a query on the Clinical Data Warehouse (CDW) based on the electronic medical records of our institution, a total of 2384 adult patients were identified who underwent 5-year or longer interval serial contrast CT scans visualizing the entire thoracic aorta. Patients who underwent surgical replacement or thoracic endovascular aortic repair (TEVAR) of any segment of thoracic aorta were excluded. The diameter of the aorta was compared at five levels (sinus of Valsalva, ascending aorta, aortic arch, proximal and distal descending thoracic aorta) between the first and last images which had taken with the mean interval of 7.3 ± 1.1 years. The mean age at the first CT scanning was 58.1 ± 12.1 years.
Results : The initial diameter was significantly larger at all levels of the thoracic aorta in male patients and those who have larger body mass index (p<0.01). At both genders and at all levels, the indexed aortic diameter (diameter divided by body mass index) was larger in the older groups. The mean indexed diameter of the ascending aorta increased from 1.15 cm/m2 at the age of 20’s to 1.79 cm/m2 at the 80’s. The mean growth rate (MGR, mm/year) was higher at the proximal aorta; 0.16 ± 0.43 at the sinus of Valsalva, 0.15 ± 0.27 at the ascending aorta, 0.11 ± 0.64 at the arch, and 0.09 ± 0.33 at the proximal descending aorta. MGRs at the ascending, proximal and distal descending thoracic aorta were highest in the age of forties, and gradually decreased with the age (p<0.01). The initial diameter showed negative correlation with MGR at all levels (p<0.01). The endpoint of significant (>5mm) dilatation of any aortic segment was significantly correlated only with the time interval of CT scanning but not with age, sex, initial diameter, or body mass index.
Conclusion : We confirmed that the thoracic aorta of general adult population continuously dilates with aging, most prominently at the aortic root and ascending aorta. Further study is needed to investigate the correlation between the aortic dilatation and risk factors such as hypertension, smoking, etc.
Methods : By performing a query on the Clinical Data Warehouse (CDW) based on the electronic medical records of our institution, a total of 2384 adult patients were identified who underwent 5-year or longer interval serial contrast CT scans visualizing the entire thoracic aorta. Patients who underwent surgical replacement or thoracic endovascular aortic repair (TEVAR) of any segment of thoracic aorta were excluded. The diameter of the aorta was compared at five levels (sinus of Valsalva, ascending aorta, aortic arch, proximal and distal descending thoracic aorta) between the first and last images which had taken with the mean interval of 7.3 ± 1.1 years. The mean age at the first CT scanning was 58.1 ± 12.1 years.
Results : The initial diameter was significantly larger at all levels of the thoracic aorta in male patients and those who have larger body mass index (p<0.01). At both genders and at all levels, the indexed aortic diameter (diameter divided by body mass index) was larger in the older groups. The mean indexed diameter of the ascending aorta increased from 1.15 cm/m2 at the age of 20’s to 1.79 cm/m2 at the 80’s. The mean growth rate (MGR, mm/year) was higher at the proximal aorta; 0.16 ± 0.43 at the sinus of Valsalva, 0.15 ± 0.27 at the ascending aorta, 0.11 ± 0.64 at the arch, and 0.09 ± 0.33 at the proximal descending aorta. MGRs at the ascending, proximal and distal descending thoracic aorta were highest in the age of forties, and gradually decreased with the age (p<0.01). The initial diameter showed negative correlation with MGR at all levels (p<0.01). The endpoint of significant (>5mm) dilatation of any aortic segment was significantly correlated only with the time interval of CT scanning but not with age, sex, initial diameter, or body mass index.
Conclusion : We confirmed that the thoracic aorta of general adult population continuously dilates with aging, most prominently at the aortic root and ascending aorta. Further study is needed to investigate the correlation between the aortic dilatation and risk factors such as hypertension, smoking, etc.
책임저자: 박계현
서울대학교 의과대학 분당서울대학교병원 흉부외과학교실
연락처 : 김수현, Tel: 010-3413-0405 , E-mail : annesue01@gmail.com
