초록접수 현황
| 15F-002 | 구연 발표 |
Pulse Wave Velocity is Associated with Reduced Renal Function and Diastolic Myocardial Dysfunction after Cardiac Surgery
최재성¹, 오세진¹, 김학령², 성용원¹, 문현종¹, 이정상¹
서울특별시 보라매병원 흉부외과학교실¹, 서울특별시 보라매병원 순환기내과²
Background : Arterial stiffness (AS) is a useful non-invasive marker of cardiovascular complications. This study investigated the association between brachial-ankle pulse wave velocity (baPWV) and post-cardiac surgery morbidity.
Methods : Among 62 patients without known comorbidities enrolled at a single center, 60 (mean age: 66.8±9.1 years, 53.3% males) completed measurements of baseline baPWV and postoperative morbidity parameter. Tissue Doppler echocardiographic data were analyzed only for patients who underwent non-valvular operations (NV).
Results : In univariate analysis, the postoperative estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) stages were significantly associated with baPWV (p = 0.024, β = -1.535; p = 0.010, β = 0.170, respectively) with statistical significance maintained (p = 0.014, β = -1.379; p = 0.038, β = 0.225, respectively) even after adjustment for confounders including age, sex, hypertension, diabetes, operation types, cardiopulmonary bypass, and baseline eGFR. In receiver-operating characteristic curve analysis of patients undergoing NV for detection of postoperative eGFR < 50 mL/min/1.73 m2, the cut-off value of baPWV was 18.0 m/s with 64.3% sensitivity and 75.0% specificity (area under the curve, 0.783; confidence interval, 0.631–0.934; p = 0.004). Mean early velocity, measured at the septal mitral annulus (E′) of the patients undergoing NV, was inversely associated with preoperative quartile of baPWV, both in univariate (p = 0.009) and multivariate (p = 0.010) linear regression analyses.
Conclusion : Increasing baseline AS was independently associated with the decline of postoperative renal and left ventricular diastolic functions.
Methods : Among 62 patients without known comorbidities enrolled at a single center, 60 (mean age: 66.8±9.1 years, 53.3% males) completed measurements of baseline baPWV and postoperative morbidity parameter. Tissue Doppler echocardiographic data were analyzed only for patients who underwent non-valvular operations (NV).
Results : In univariate analysis, the postoperative estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) stages were significantly associated with baPWV (p = 0.024, β = -1.535; p = 0.010, β = 0.170, respectively) with statistical significance maintained (p = 0.014, β = -1.379; p = 0.038, β = 0.225, respectively) even after adjustment for confounders including age, sex, hypertension, diabetes, operation types, cardiopulmonary bypass, and baseline eGFR. In receiver-operating characteristic curve analysis of patients undergoing NV for detection of postoperative eGFR < 50 mL/min/1.73 m2, the cut-off value of baPWV was 18.0 m/s with 64.3% sensitivity and 75.0% specificity (area under the curve, 0.783; confidence interval, 0.631–0.934; p = 0.004). Mean early velocity, measured at the septal mitral annulus (E′) of the patients undergoing NV, was inversely associated with preoperative quartile of baPWV, both in univariate (p = 0.009) and multivariate (p = 0.010) linear regression analyses.
Conclusion : Increasing baseline AS was independently associated with the decline of postoperative renal and left ventricular diastolic functions.
책임저자: 최재성
서울특별시 보라매병원 흉부외과학교실
연락처 : 최재성, Tel: 02-870-2293 , E-mail : turejsreal@hanmail.net
