초록접수 현황
| 14F-275 | 구연 발표 |
Intramural metastasis as a risk factor for recurrence in patients with esophageal squamous cell carcinoma
전재현, 양희철, 김문수, 이종목
국립암센터 폐암센터
Background : The purpose of this study was to assess the clinicopathologic implications of intramural metastasis in patients with esophageal squamous cell carcinoma (ESCC).
Methods : We retrospectively analyzed the medical records of 730 patients who underwent esophagectomy without neoadjuvant therapy. Among these patients, intramural metastasis was detected in 39 patients (5.3%). The patterns of intramural metastasis were investigated and clinico-pathologic features were analyzed to define risk factors for recurrence.
Results : There were 694 male patients with a mean age of 64.4 ± 7.8 years. The median follow-up period was 32.2 months. Intramural metastasis was associated with advanced T stage (p < 0.0001), N stage (p < 0.0001), and poor differentiated lesions (p = 0.012). The median size of intramural metastasis was 2.5 cm (range: 0.7~6.4), and the median distance from primary tumor to metastasis was 3.0 cm (range: 0.5~21.0). Multiple metastases were observed in 46.2 % of cases. Intramural metastasis was detected preoperatively in 52.6 % of cases and was present equally on both sides of the primary lesion. In multivariate analysis, advanced T-stage (p < 0.001), advanced N-stage (p < 0.001), and presence of intramural metastasis (p = 0.015) were independent risk factors for recurrence. The 3-year recurrence-free survival (FRS) was 13.3% for patients with intramural metastasis and 51.1% for those without (p < 0.001).
Conclusion : Intramural metastasis could be important prognostic factors, along with anatomical determinants such as TNM staging system in patients with ESCC. Effective surveillance and individualized adjuvant therapy may help improve the outcome of patients with ESCC, particularly when accompanied by intramural metastasis.
Methods : We retrospectively analyzed the medical records of 730 patients who underwent esophagectomy without neoadjuvant therapy. Among these patients, intramural metastasis was detected in 39 patients (5.3%). The patterns of intramural metastasis were investigated and clinico-pathologic features were analyzed to define risk factors for recurrence.
Results : There were 694 male patients with a mean age of 64.4 ± 7.8 years. The median follow-up period was 32.2 months. Intramural metastasis was associated with advanced T stage (p < 0.0001), N stage (p < 0.0001), and poor differentiated lesions (p = 0.012). The median size of intramural metastasis was 2.5 cm (range: 0.7~6.4), and the median distance from primary tumor to metastasis was 3.0 cm (range: 0.5~21.0). Multiple metastases were observed in 46.2 % of cases. Intramural metastasis was detected preoperatively in 52.6 % of cases and was present equally on both sides of the primary lesion. In multivariate analysis, advanced T-stage (p < 0.001), advanced N-stage (p < 0.001), and presence of intramural metastasis (p = 0.015) were independent risk factors for recurrence. The 3-year recurrence-free survival (FRS) was 13.3% for patients with intramural metastasis and 51.1% for those without (p < 0.001).
Conclusion : Intramural metastasis could be important prognostic factors, along with anatomical determinants such as TNM staging system in patients with ESCC. Effective surveillance and individualized adjuvant therapy may help improve the outcome of patients with ESCC, particularly when accompanied by intramural metastasis.
책임저자: 이종목
국립암센터 폐암센터
연락처 : 전재현, Tel: 031-920-1708 , E-mail : fine1114@hanmail.net
