초록접수 현황
| 14F-197 | 구연 발표 |
The Value of 18F-fluorodeoxyglucose Positron Emission Tomography/computed Tomography for Predicting the World Health Organization Malignant Grade of Thymic Epithelial Tumors: Focused in Volume-dependent Parameters
정희석1, 유우식1, 박성용2, 배미경3, 이창영1, 이진구1, 김대준1, 정경영1
1.연세대학교 흉부외과학교실 2.아주대학교 흉부외과학교실 3.서울대학교 흉부외과학교실
Background : The objective of this study was to investigate whether the maximum standardized uptake value (SUVmax) and volume dependent parameters determined using 18F-fluorodeoxyglucose Positron Emission Tomography/Computed tomography (18F-FDG PET/CT) is correlated with the grade of malignancy of thymic epithelial tumors based on the World Health Organization (WHO) classification and Masaoka stage or not.
Methods : We retrospectively reviewed 61 patients who diagnosed as thymoma or thymic carcinoma after surgical resection with PET/CT. A region of interest was drawn on the primary lesion, and using a SUV cut-off of 2.5, metabolic indices such as SUVmax, SUVmax/Tumor size, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured.
Results : There were 24 (38.7%) male patients and mean age was 50.23±12.54 years. Mean tumor size was 6.11±3.41cm. There were 22(36.9%) low risk thymomas (A, AB, B1), 32(51.6%) high risk thymomas and 7(11.5%) thymic carcinomas. Masaoka stage was I in 15(24.6%), II in 30(49.2%), III in 11(18.0%) and IV in 5(8.2%) patients. Mean SUVmax was 3.43±1.01 in low risk thymomas, 4.42±1.70 in high risk thymoma, 8.23±2.61 in thymic carcinoma and the differences were statistically significant (p<0.001). Mean MTV and TLG were 90.74±114.56 and 229.36±300.56 in low risk thymomas, 80.82±112.49 and 233.93±340.91 in high risk thymoma and 90.63±90.74 and 390.94±437.62 in thymic carcinoma. The MTV and TLG were not correlated with WHO classification. On ROC curve analysis, the cut-off value for discriminating the thymoma and thymic carcinoma was 5.05. SUVmax and TLG were also correlated with Masaoka Stage.
Conclusion : Although volume dependent parameters such as TLG and MTV were not correlated with WHO classification, a significant relationship was observed between SUVmax and morphological classification by the WHO classification, and Masaoka stage.
Methods : We retrospectively reviewed 61 patients who diagnosed as thymoma or thymic carcinoma after surgical resection with PET/CT. A region of interest was drawn on the primary lesion, and using a SUV cut-off of 2.5, metabolic indices such as SUVmax, SUVmax/Tumor size, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured.
Results : There were 24 (38.7%) male patients and mean age was 50.23±12.54 years. Mean tumor size was 6.11±3.41cm. There were 22(36.9%) low risk thymomas (A, AB, B1), 32(51.6%) high risk thymomas and 7(11.5%) thymic carcinomas. Masaoka stage was I in 15(24.6%), II in 30(49.2%), III in 11(18.0%) and IV in 5(8.2%) patients. Mean SUVmax was 3.43±1.01 in low risk thymomas, 4.42±1.70 in high risk thymoma, 8.23±2.61 in thymic carcinoma and the differences were statistically significant (p<0.001). Mean MTV and TLG were 90.74±114.56 and 229.36±300.56 in low risk thymomas, 80.82±112.49 and 233.93±340.91 in high risk thymoma and 90.63±90.74 and 390.94±437.62 in thymic carcinoma. The MTV and TLG were not correlated with WHO classification. On ROC curve analysis, the cut-off value for discriminating the thymoma and thymic carcinoma was 5.05. SUVmax and TLG were also correlated with Masaoka Stage.
Conclusion : Although volume dependent parameters such as TLG and MTV were not correlated with WHO classification, a significant relationship was observed between SUVmax and morphological classification by the WHO classification, and Masaoka stage.
책임저자: 정경영
연세대학교 흉부외과학교실
연락처 : 정희석, Tel: 02-2228-2140 , E-mail : hsjung80@yuhs.ac
