초록접수 현황
| 14F-115 | 구연 발표 |
Prognostic Value of Total Lesion Glycolysis by 18F-fluorodeoxyglucose Positron Emission Tomography/computed Tomography in Surgically Resected Stage IA Non-small Cell Lung Cancer
유우식¹, 정희석¹, 박성용², 이창영¹, 이진구¹, 김대준¹, 정경영¹
연세대학교 의과대학 세브란스병원 흉부외과학교실¹,
, 아주대학교 의과대학 흉부외과학교실²
Background : Despite the favorable prognosis of stage IA non-small cell lung cancer (NSCLC) recurrence after complete surgical resection occurs in 20%–30% of patients. This study determined the prognostic value of various metabolic parameters of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in surgically resected stage IA NSCLC.
Methods : We retrospectively reviewed 248 patients with stage IA NSCLC who underwent lobectomy and complete lymph node dissection after PET/CT. A region of interest was drawn on the primary lesion and metabolic indices such as metabolic tumor volume (MTV), maximum standardized uptake value (SUVmax), and total lesion glycolysis (TLG) were measured using a SUV cut-off of 2.5.
Results : The patients included 134 males and mean age was 63.03 ± 10.01 years; 129 were tumor stage T1a (≤2 cm) and 119 were T2a (>2 cm). The median follow-up period was 36.6 months. Recurrences occurred in 15 patients. The mean SUVmax, MTV, TLG were 4.55 ± 3.75, 5.92 ± 5.57, and 14.42 ± 17.35, respectively. The cut-off value of SUVmax and TLG were 3.7 and 13.76, respectively. The 5-year overall survival (OS) was 95.1% in low-SUVmax patients and 82.2% in high-SUVmax patients (p=0.02). The 5-year OS was 93.7% in low-TLG patients and 78.3% in high-TLG patients (p=0.01). On multivariate analysis, TLG was a risk factor for OS (hazard ratio=3.159, p=0.040) but SUVmax showed marginal significance (p=0.064). The concordance index of the TLG model was 0.676 (95% CI 0.541–0.812).
Conclusion : TLG was a significant prognostic factor for OS in patients with stage IA NSCLC.
Methods : We retrospectively reviewed 248 patients with stage IA NSCLC who underwent lobectomy and complete lymph node dissection after PET/CT. A region of interest was drawn on the primary lesion and metabolic indices such as metabolic tumor volume (MTV), maximum standardized uptake value (SUVmax), and total lesion glycolysis (TLG) were measured using a SUV cut-off of 2.5.
Results : The patients included 134 males and mean age was 63.03 ± 10.01 years; 129 were tumor stage T1a (≤2 cm) and 119 were T2a (>2 cm). The median follow-up period was 36.6 months. Recurrences occurred in 15 patients. The mean SUVmax, MTV, TLG were 4.55 ± 3.75, 5.92 ± 5.57, and 14.42 ± 17.35, respectively. The cut-off value of SUVmax and TLG were 3.7 and 13.76, respectively. The 5-year overall survival (OS) was 95.1% in low-SUVmax patients and 82.2% in high-SUVmax patients (p=0.02). The 5-year OS was 93.7% in low-TLG patients and 78.3% in high-TLG patients (p=0.01). On multivariate analysis, TLG was a risk factor for OS (hazard ratio=3.159, p=0.040) but SUVmax showed marginal significance (p=0.064). The concordance index of the TLG model was 0.676 (95% CI 0.541–0.812).
Conclusion : TLG was a significant prognostic factor for OS in patients with stage IA NSCLC.
책임저자: 정경영
연세대학교 의과대학 세브란스병원 흉부외과학교실
연락처 : 유우식, Tel: 02-2227-4476 , E-mail : yws081011@yuhs.ac
